Betting
Bills vs Eagles Preview: Odds, Tips and Prediction
SportsBoom Previews the NFL match between the Buffalo Bills and the Philadelphia Eagles at Highmark Stadium, Orchard Park, New York, on Sunday, 28th, 2025. It’s a highly significant clash with playoff seeding up for grabs for both teams, and the top NFL betting sites have a strong range of markets and competitive odds for this showdown.
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How to Watch Buffalo Bills vs Philadelphia Eagles
- Date: Sunday, Dec 28th, 2025
- Tip-Off Time: 4:25 p.m. ET
- Venue: Highmark Stadium, Orchard Park, New York
- TV: FOX
- Streaming: RochesterFirst streaming app
- Records: Buffalo Bills (11-4), Philadelphia Eagles (10-5)
Pre-Game Odds and Win Probability
Eagles: 26/25(2.04) – 49%
Bills: 69/100 (1.69)- 59.2%
*Odds courtesy of N1 Bet, subject to change
Head-to-Head Record
Last five meetings (NFL)
26/11/2023 Philadelphia Eagles 37-34 (Overtime) Buffalo Bills at Lincoln Financial Field
27/10/2029 Buffalo Bills 13-31 Philadelphia Eagles at Highmark Stadium
13/12/2015 Philadelphia Eagles 23-20 Buffalo Bills at Lincoln Financial Field
09/10/2011 Buffalo Bills 31-24 Philadelphia Eagles at Highmark Stadium
30/12/2007 Philadelphia Eagles 17-9 Buffalo Bills at Lincoln Financial Field
The Bills vs. Eagles rivalry has been played 15 times, with the Buffalo Bills winning 6 games and the Philadelphia Eagles winning 9 games.
Buffalo Bills: Current Form- WWWWL (Last 5 results)
The Buffalo Bills are currently on a four-game winning streak that came after losing 23-19 against the Texans.
The Bills’ offense, led by MVP quarterback Josh Allen, is a highly efficient unit known for its potent rushing attack and dynamic play-extending capabilities. It currently ranks as one of the best in the NFL with 28.9 points per game, 158.9 rushing yards per game (1st in the NFL), and 214.2 passing yards per game.
On the other hand, their defense is ranked 12th in the NFL. Their pass defense is one of the best in the NFL, as it allows 169.5 passing yards per game, the second fewest in the NFL behind the Browns.
Buffalo Bills Offense vs Philadelphia Eagles Defense
The Bills’ offense has it all. They boast a dual-threat quarterback in Josh Allen, a dominant running game, strategic playcalling by their offensive coordinator Joe Brady, and effective wide receivers. They are brilliant in a clutch situation.
The Eagles’ defense has transformed into an elite unit this season. Payers have acclimatized well and enabled them to become one of the NFL’s best defenses.
Key Players to Watch
- Josh Allen (Quarterback): The reigning MVP is once again carrying the Bills team singlehandedly with otherworldly performances to boot. Allen has accumulated 25 touchdowns, 3406 passing yards, and ten interceptions.
- James Cook (Running back): Aside from his recent fumbling yards, James Cook has been an elusive battering ram for the Bills. The fourth year running back has 12 touchdowns and has attempted 287 rushes for 1532 yards.
- Khalil Shakir (Wide Receiver): Khalil Shakir’s connection with Josh Allen is just poetic. The speedster has accrued four touchdowns, 66 receptions, and 684 receiving yards.
Buffalo Bills Injury Report
Chase Lundt, Ed Olive, Tyler Bass, Michael Hoecht, Taylor Rapp, DeWayne Carter, and Wande Owens will be out of this showdown after suffering respective Knee, Bicep, left hip, groin, Achilles, and Achilles injuries.
The Bills have adequate coverage, and these injuries will be covered.
Philadelphia Eagles Form- WWLLL (Last 5 Results)
The Eagles made it two wins in a row after beating the Commanders 29-18. The Eagles’ offense has been underperforming despite being talented. Consistency has been a problem, and the rushing efficiency has gone down, with star running back Saquon Barkley's underperformance being at fault. Offensive injuries have also affected the team’s chemistry.
On the other hand, their defense has been their driving force, allowing the offense to win games with single touchdowns. Their trade deadline accusations have been humongous as they have enabled the team to build a dominant pass-rushing and stifle pass-denying unit that is physical, disciplined, and well-coached.
Philadelphia Eagles – Offense vs Buffalo Bills Defense
The Eagles’ offense has the talent, but underperformance has been a big concern. Despite strong play from QB Jalen Hurts and talented receivers like A.J. Brown and DeVonta Smith, the Eagles lack rhythm and creativity, which has resulted in low ranks in yards, scoring, and efficiency.
The Bills’ defense has been one of the best, but they will need to balance their performances as they rank highly in the pass defense and average in rushing defense.
Key Players to Watch
- Jalen Hurts (Quarterback): The reigning Super Bowl MVP has been solid despite the Eagles’ offense struggling. Hurts has tallied 24 touchdowns, 3115 passing yards, and six interceptions.
- Saquon Barkley (Running back): Despite an underwhelming season, Barkley has accumulated 1072 yards on 261 carries and seven touchdowns. He will be instrumental against the Bills, who struggle to defend the rushing game.
- Zack Baun (Linebacker): Zack Baun has been massive for the Eagles’ defense, which has dominated the league. He has registered 58 solo tackles, 3.5 sacks, two interceptions, and a forced fumble.
Philadelphia Eagles Injury Report
Myles Hinton, Willie Lampkin, Ogbo Okoronkwo, and Johnny Wilson will be absent after suffering respective back, knee, tricep, and knee injuries.
The Eagles will replace these injured players without any concern of a dip in performance.
Predicted Line-Ups (Offense & Defense)
Buffalo Bills
- Offense:
QB: Josh Allen
RB: James Cook III
WR: Khalil Shakir, Joshua Palmer, and Tyrell Shavers
TE: Dalton Kincaid
OL: Reggie Gilliam, Dion Dawkins, David Edwards, Connor McGovern, O’Cyrus Torrence, and Spencer Brown - Defense:
DE: Greg Rousseau and Joey Bosa
DT: Deone Walker and DaQuan Jones
LB: Matt Milano, Terrel Bernard, Shaq Thompson, and Taron Johnson
CB: Tre’Davious White and Christian Benford
S: Jordan Poyer and Cole Bishop
Philadelphia Eagles
- Offense:
QB: Jalen Hurts
RB: Saquon Barkley
WR: A.J. Brown, DeVonta Smith, and Jahan Dotson
TE: Dallas Goedert
OL: Jordan Mailata, Landon Dickerson, Cam Jurgens, Tyler Steen, Fred Johnson, and Brett Toth - Defense:
DE: Moro Ojomo and Ty Robinson
DT: Jordan Davis
LB: Jaelan Phillips, Zack Baun, Nakobe Dean, Nolan Smith Jr., and Cooper DeJean
CB: Adoree' Jackson and Quinyon Mitchell
S: Reed Blankenship and Marcus Epps
Suggested Main Bets
Before placing your wagers, it’s worth checking betting sites in the USA for the best prices on moneyline, spreads, and totals.
Bills to Win: The Eagles’ offense has not showcased enough prowess to put off the Bills. Moreover, this will be a home game for the Bills, so they will go all out to secure a win.
Bills to cover -2.5 Point Spread: The Buffalo roster has not been entirely free of shortcomings; nonetheless, their superior quarterback, Josh Allen, will be looking to put points on the board.
Total Points – Over 45.5: Despite Philadelphia’s offense having some notable loopholes, the unit will be fighting to move the ball past the Bills. On the other hand, the hosts have a fierce offense that will equally be seeking to drive points home. Therefore, this total is well achievable.
Prop Bets & Same-Game Parlay Ideas
Bills Total Points: Over 23.5 points – They have the best quarterback in the league, and also, the Bills have demonstrated intelligent game management and have the clutch gene.
James Cook to make over 100 Rushing Yards – Cook is one of the most explosive rushing yards in the league and has demonstrated in-game intelligence that has benefited the team in coverage.
Why the Bill Team Can Win
- This will be a home game, giving them an upper hand in ensuring that victory remains in the local vicinity.
- The Bills are locked in a tight race for the AFC East division title and will definitely be keen to maintain a clean sheet of wins, not to relinquish this prestigious position to the Patriots.
Expert Prediction:
The Bills are in dire need of a victory because they are more vulnerable, a division title to clinch, and a playoff berth in sight. As a result, a win in the upcoming contests, including this one, will thrust them steps close to these realities.
Ian Wanyeki is a Nairobi-based sports journalist with a strong passion for sport and an impressive grasp of multiple disciplines. A Bachelor of Science graduate from Kenyatta University, he has worked as a sports analyst at Covenant Television Network, a sports reporter at NTV, and a correspondent and contributor for Quartz Africa.
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