Betting
Cowboys Vs Chargers Preview: Odds, Tips and Prediction
The Week 15 game was a bitter moment for the Cowboys after receiving a devastating 26-34 loss to the Vikings. Their chance of getting to the postseason is 1% and for the Chargers, their road to the playoffs is unstoppable. As you bet on this game, check out the NFL welcome offers on SportsBoom.
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Dak Prescott/Getty Images
How to Watch Cowboys Vs Chargers
- Date: Sunday, December 21, 2025
- Tip-Off Time: 6:00 PM UTC
- Venue: AT&T Stadium, Arlington
- TV/Streaming: FOX/NFL+
- Record: Cowboys: 6-7-1 vs Chargers: 10-4
Pre-game Odds and Win Probability: Cowboys Slight Favorites
Cowboys: 87/100 (1.87) – 53.5%
Chargers: 19/20 (1.95)- 51.3%
*Odds courtesy of Betway, subject to change
Head-to-Head Record
| Date | Venue | Score |
| 10/16/2023 | AT&T Stadium, Arlington | Cowboys 20 – Chargers 17 |
| 09/19/2021 | SoFi Stadium, Inglewood | Cowboys 20 – Chargers 17 |
| 11/23/2017 | SoFi Stadium, Inglewood | Chargers 28 – Cowboys 6 |
| 09/29/2013 | AT&T Stadium, Arlington | Cowboys 21 – Chargers 30 |
| 12/13/2009 | AT&T Stadium, Arlington | Chargers 20 – Cowboys 17 |
This head-to-head record reveals that the Cowboys have dominated in three out of five games, with the wins majorly occurring in home games.
Cowboys – Current Form & Matchup (WWWLL)
The Cowboys’ performance has been a blend of wins and losses, with their last two games ending in disappointing losses. In the Week 15 game against the Vikings, the Cowboys suffered a disappointing 26-34 loss that dashed their hopes of making the postseason.
The two most recent losses highlighted defensive issues in the Cowboys' lineup, right from the kick-off. Having allowed the Vikings defense to dictate them in Week 15, the Cowboys have automatically been thrown off the wild-card pursuit and will now have to hold on tight, hoping that the Philadelphia Eagles emerge losers in all their remaining contests.
Cowboys Offense vs Chargers Defense
- The Cowboys' high-powered, elite offense is a stark contrast to the team’s struggling defense. The high-scoring offense averaged 31.7 points per game and 404.3 yards per game through week 8 and week 4, respectively.
- The Chargers feature a high-ranking overall defense, and as of week 14, they had an average of 282.2 defense yards and 29 touchdowns allowed. Compared to their competitors’ defense, the Chargers' defense is one to vouch for.
Key Players to Watch (Cowboys)
- Dak Prescott (QB) – Prescott is the Cowboys’ leading offensive member, given his outstanding track record. In the just-concluded game against the Vikings, he completed 23 out of 38 passes for 294 yards. He is expected to bounce back in the game against the Chargers.
- George Pickens (WR) – Pickens has not been at his best performance in Weeks 14 and 15. He is expected to get back on track in this tough matchup, hoping that his yardage will be on the rise in this game.
- Javonte Williams (RB) – Williams rushed the ball 15 times for 91 yards in the game against the Vikings, and he scored a touchdown. He has made a solid bounce-back in the game in Week 15, and it is expected that he will make chunk gains of yards in this upcoming game against the Chargers.
Cowboys Injury Report
Trevon Diggs (CB) and Tyler Guyton (OL) will be out of this matchup due to knee and ankle injuries, respectively. On the other hand, Jadeveon Clowney (DE) and Jake Ferguson (TE) remain questionable due to Hamstring and calf injuries, respectively. Trevon Digg’s injury might have a more debilitating impact on the already shaky defense of the Cowboys.
Chargers – Current Form & Matchup (WLWWW)
The Chargers hold a 10-4 record and are currently the AFC’s leading wild-card team. Their recent performance has been remarkable, having won four out of their five games. In Week 15, they recorded a 16-13 win against the Chiefs. In Week 14 and Week 13, they won against the Eagles (22-19) and the Raiders (31-14), respectively. Nonetheless, the loss against the Jaguars (6-35) was quite devastating.
In all their wins, the Charges have featured dominant defense and an equally strong offense. If the Chargers maintain their recent momentum in this matchup, they will move closer to a playoff berth.
Chargers Offense vs Cowboys Defense
- The Chargers have a versatile but quite inconsistent offensive line that is led by Justin Herbert. The teams have been battling offensive injuries and face major challenges in overcoming solid defenses.
- The Cowboys’ weak defense has been more of a liability and is especially vulnerable to passes, having allowed more than 40 points in several games during the 2025 season.
Key Players to Watch (Chargers)
- Justin Herbert (QB) – For 210 yards, Herbert completed 19 of 29 passes in the matchup against the Chiefs. In this matchup, Herbert is expected to continue spearheading the Chargers' offensive line.
- Kimani Vidal (RB) – He rushed 12 times for 33 yards, and he extended his streak of consecutive games with double digits. In the upcoming Week 16 game, he will be extending his robust complementary role.
- LaddMcConkey (WR) – McConkey will be looking to capitalize on the Cowboys’ inconsistent defense. Therefore, his performance is expected to be on the rise in this game.
Chargers Injury Report
The Chargers have a sizeable number of injured players, right from Derius Davis, who is out due to an ankle injury. There is also Elijah Molden and Trey Pipkins, whose return remains doubtful due to hamstring and ankle injuries. Troy Dye and Quentin Johnston’s ability to play in this matchup remains questionable owing to their hip and groin injuries.
Predicted Line-Ups (Offense and Defense)
Dallas Cowboys
Offense:
- QB: Dak Prescott
- RB: Javonte Williams
- WR: CeeDee Lamb, George Pickens, and Ryan Flournoy
- TE: Jake Ferguson
- OL: Hunter Luepke, Nate Thomas, Tyler Smith, Cooper Beebe, Tyler Booker, and Terence Steele
Defense:
- DE: Donovan Ezeiruaku and Dante Fowler Jr.
- DT: Osa Odighizuwa and Quinnen Williams
- LB: DeMarvion Overshown, Logan Wilson, Kenneth Murray Jr., and Reddy Steward
- CB: DaRon Bland and Caelen Carson
- S: Donovan Wilson and Malik Hooker
Los Angeles Chargers
Offense:
- QB: Justin Herbert
- RB: Omarion Hampton
- WR: Ladd McConkey, Tre' Harris, and Keenan Allen
- TE: Oronde Gadsden II
- OL: Scott Matlock, Jamaree Salyer, Zion Johnson, Bradley Bozeman, Mekhi Becton, and Bobby Hart
Defense:
- DE: Da'Shawn Hand and Justin Eboigbe
- DT: Teair Tart
- LB: Tuli Tuipulotu, Daiyan Henley, Denzel Perryman, Khalil Mack, and Derwin James Jr.
- CB: Donte Jackson and Cam Hart
- S: RJ Mickens and Marcus Williams
Suggested Main Bets
These main bets are shaped by defensive matchups, point spread value, and projected scoring tempo rather than headline narratives. All of these markets are standard offerings on trusted US betting sites, giving bettors flexibility when comparing odds and totals.
Chargers to Win: Despite the Cowboys being the slight favorites in this game, the Chargers have more solid pillars on which their potential to win is hinged. The Cowboys have a lukewarm defense, and compared to the Chargers’ dominant defense and versatile offense, they might just have to take a bow.
Chargers to Cover a -1.5 Point Spread: In this game, the Chargers are expected to win by a margin that goes beyond the 1.5 spread mark. We look up to another straight win for the Chargers, one with more than a two-point gap.
Total Points: Under 49.5: The Cowboys have a leaking defense but their offense, however, has been performing exemplary well, but they will need to be well-charged to overcome the Chargers’ strong defense. Considering these aspects, the game is not expected to surpass the 49.5 threshold.
Game Props & Same-Game Parlays Ideas
Each Team will score more than 20 points: This game will most likely be highly competitive, hence, both teams are expected to achieve this target.
Cowboys to make over 2.5 total touchdowns: George Pickens will be looking to deliver a well-coordinated performance in this game, given the Cowboys' stringent position. Therefore, this is a probable outcome
Why Chargers Can Win
- Chargers feature a dominant defense that has made a statement to the league that they can carry the team into the playoffs, which includes recording a win over the Cowboys.
- Although the Cowboys have one of the best offensive lines, led by Dak Prescott, the Chargers are known to rush with discipline, hence are likely to limit his escape and collapse the pocket.
Expert Prediction: Chargers to Win
The Chargers’ performance has surged, winning three consecutive games, thanks to their defense. They have rattled some of the leading quarterbacks in the league and forced turnovers.
Just as the Chargers dominated the Chiefs in their road game, they may as well replicate that same outcome in this matchup, recording another win and continually sealing the postseason position.
Ian Wanyeki is a Nairobi-based sports journalist with a strong passion for sport and an impressive grasp of multiple disciplines. A Bachelor of Science graduate from Kenyatta University, he has worked as a sports analyst at Covenant Television Network, a sports reporter at NTV, and a correspondent and contributor for Quartz Africa.