Best NFL Betting Sites 2025 - Top Picks for American Football

One of the most important aspects of any sports betting site is the odds and markets that they offer to players. Look for sportsbooks that offer competitive odds across the wide range of bet types, including moneylines, point spreads, totals, player props, futures and more.

The more options offered, the more opportunities you will have to spot value.

Quality sportsbooks often give potential players enticing bonus and promotion offers, plus they also have lucrative offers to keep existing players with their sportsbook. Bonus types include welcome bonuses, reload bonuses, free bets, and even VIP rewards programs. Just make sure you always read the terms and conditions before you accept a promotion, as there are often wagering requirements and other limitations.

As the games progress (in NFL and other sports), the odds change. One of the most exciting features in today's age of sports betting is in-game betting, giving you the opportunity to make a bet starting in the middle of the game. Odds are adjusted based on the new likeliest outcomes, based on what has previously happened in the game.

Nowadays, a good mobile web site experience is essential for sports bettors. Look for sites with well-designed and mobile optimized web sites and apps. Test to make sure that apps work when mobile coverage isn't at its best. You don't want to miss an opportunity to place that bet near kickoff.

A good indicator of a sportsbook's reputation and customer service is their social media presence. Additionally, look for sportsbooks that have multiple avenues for contact, including live agent chat, e-mail, phone support, and/or a ticket system.

The point spread is one of the most common bets in the NFL. In this wager, the favored team must win by a certain number of points (the spread) for a bet on them to be successful. Conversely, the underdog can lose by less than the spread or win outright for the bet to pay out. For example the Chiefs to win by 7 over the Bills, means the Chiefs are favored by 7 points. 

The money line is a straightforward bet on which team will win the game outright, regardless of the point spread. Favorites will have negative odds (e.g., -150), meaning you'd need to risk $150 to win $100. Underdogs will have positive odds (e.g., +130), where a $100 wager would net you $130 in profit if successful. If you can start putting some moneyline bets together in a parlay, then you can rake in some big time cash.

In a total bet, you're wagering on whether the combined score of both teams will go over or under a predetermined number set by the sportsbook. These bets are not tied to who wins the game, only the total points scored. So if the total of the Chiefs vs Bills game is 48, if the combined points of both teams are greater than 48, it’s an Over. If the total is less than 48, it’s an Under. If they hit 48 dead-on, that’s a push, and is much harder to predict. 

Prop bets, or proposition bets, allow you to wager on specific player or team milestones within a game, such as how many passing yards a quarterback will have, whether a player will score a touchdown, or the outcome of the coin toss. For example, you could bet that Patrick Mahomes might have +20 rushing yards, and +230 passing yards. Putting multiple player props together can give you a massive payout if you know what you’re doing.

Futures bets involve wagering on long-term outcomes, such as which team will win the Super Bowl, which player will win MVP, or over/under season win totals for each team. During an offseason, futures are fun to take a bet on as a pre-season prediction. With the 49ers being 5/1 favorites to win the Super Bowl in 2025, a bettor could lock in a good value bet before the season changes the odds.